Laser therapy spinal cord injury

Light promotes regeneration and functional recovery and changes the immune response after a spinal cord injury

Byrnes KR; Waynant RW; Ilev IK; Wu X; Barna L; Smith K; Heckert R; Gerst H; Anders JJ
Lasers in surgery and medicine; VOL: 36 (3); S. 171-85 /200503/
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. This email address is being protected from spambots. You need JavaScript enabled to view it.

Background and objectives: Photobiomodulation (PBM) has been proposed as a potential therapy for spinal cord injury (SCI). We wanted to show that 810 nm light can penetrate deep into the body and promote neuronal regeneration and functional recovery.

The methods: Adult rats underwent a T9 dorsal hemisection followed by treatment with an 810 nm, 150 mW diode laser (dose = 1,589 J/cm2). Axonal regeneration and functional recovery were assessed using single and double label tracing and various musculoskeletal tasks. The immune response within the spinal cord was also assessed.

Results: PBM with a 6% power penetration into the depth of the spinal cord significantly increased the number of axons and the distance of regrowth (P < 0.001). PBM also restored aspects of function to baseline levels and significantly suppressed immune cell activation and cytokine/chemokine expression.

Schlussfolgerung: Unsere Ergebnisse zeigen, dass Licht, transkutan appliziert, die Genesung nach der Verletzung verbessert, und legen nahe, dass Licht eine nützliche Behandlung für menschliche SCI sein wird. - CNOTE: Urheberrecht 2005 Wiley-Liss, Inc